Irina Saltykova, Ph.D.

My long-term goal is to utilize my training in mouse gene targeting, molecular biology and retinal physiology to develop new therapeutic approaches for vision restoration. Specifically, I aim to develop therapies that unlock the potential of mammalian Müller glial cells to regenerate new retinal neurons.

Publications

1.     Pitale PM, Saltykova IV, Adu-Agyeiwaah Y, Calzi SL, Satoh T, Akira S, Gorbatyuk O, Boulton ME, Pardue MT, Garvey WT, Athar M, Grant MB, Gorbatyuk MS. Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy. Diabetes. 2021 Aug;70(8):1738-1753.

2.     Saltykova IV., Elahi, A., Pitale, P.M. et al. Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration. Cell Death Dis 12, 664 (2021).

3.     Gorbatyuk OS, Pitale PM, Saltykova IV, Dorofeeva IB, Zhylkibayev AA, Athar M, Fuchs PA, Samuels BC, Gorbatyuk MS. A Novel Tree Shrew Model of Diabetic Retinopathy. Front Endocrinol (Lausanne). 2022 Jan 3;12:799711.

4.     Saltykova IV, Zhylkibayev A, Gorbatyuk OS, Gorbatyuk MS. GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice. Int J Mol Sci. 2022 Nov 9;23(22):13748.

5.     Dorofeeva I, Zhylkibayev A, Saltykova IV, Atigadda V, Adhikari B, Gorbatyuk OS, Grant MB, Gorbatyuk MS. Retinoid X Receptor Activation Prevents Diabetic Retinopathy in Murine Models. Cells. 2023 Sep 26;12(19):2361.Saltykova IV, Bragina E.Yu., Ogorodova L.M., Puzyrev V.P., Freidin M.B. Opisthorchis felineus liver fluke invasion is an environment factor modifying genetic risk of atopic bronchial asthma. Acta Trop. 2014;139:53-6.

6.     Ogorodova L.M., Fedorova O.S., Sripa B., Mordvinov V.A., Katokhin A.V., KeiserJ., Odermatt P., Brindley P.J., Mayboroda O.A., Velavan T.P., Freidin M.B., Sazonov A.E., Saltykova IV, Pakharukova M.Y., Kovshirina Y.V., Kaloulis K., Krylova O.Y., Yazdanbakhsh M. Opisthorchiasis: an overlooked danger. PLoS Negl Trop Dis. 2015 2;9(4):e0003563.

7.     Yuryeva K, Saltykova IV, Ogorodova L, Kirillova N, Kulikov E, Korotkaya E, Iakovleva Y, Feoktistov I, Sazonov A, Ryzhov S. Expression of adenosine receptors in monocytes from patients with bronchial asthma. Biochem Biophys Res Commun. 2015;464(4):1314-20.

8.     Pershina AG, Saltykova IV, Ivanov VV, Perina EA, Demin AM, Shevelev OB, Buzueva II, Gutakovskii AK, Vtorushin SV, Ganebnykh IN, Krasnov VP, Sazonov AE, Ogorodova LM. Hemozoin "knobs" in Opisthorchis felineus infected liver. Parasit Vectors. 2015;8:459.

9.     Saltykova IV, Ogorodova LM, Ivanov VV, Bogdanov AO, Gereng EA, Perina EA, Brindley PJ, Sazonov AE. Carbonyl stress phenomena during chronic infection with Opisthorchis felineus. Parasitol Int. 2016 pii: S1383-5769(16)00003-9.

10.     Saltykova IV, Petrov VA, Logacheva MD, Ivanova PG, Merzlikin NV, Sazonov AE, Ogorodova LM, Brindley PJ. Biliary Microbiota, Gallstone Disease and Infection with Opisthorchis felineus. PLoS Negl Trop Dis. 2016;10(7):e0004809.

11.     Fedorova OS, Kovshirina YV, Kovshirina AE, Fedotova MM, Deev IA, Petrovskiy FI, Filimonov AV, Dmitrieva AI, Kudyakov LA, Saltykova IV, Odermatt P, Ogorodova LM. Opisthorchis felineus infection and cholangiocarcinoma in the Russian Federation: A review of medical statistics. Parasitol Int. 2016. pii: S1383-5769(16)30236-7. doi: 10.1016/j.parint.2016.07.010.

12.     Kostidis S, Kokova D, Dementeva N, Saltykova IV, Kim HK, Choi , Mayboroda OA. 1H-NMR analysis of feces: new possibilities in the helminthes infections research. BMC Infect Dis. 2017;17(1):275.

13.     Kokova, DA.; Kostidis, S; Morello, J; Dementeva, N; Perina, EA.; Ivanov, VV.; Ogorodova, L M.; Sazonov, AE.; Saltykova IV.; Mayboroda, OA. Exploratory metabolomics study of the experimental opisthorchiasis in a laboratory animal model (golden hamster, Mesocricetus auratus). PLoS Neglected Tropical Diseases. 2017. Vol. 11 I. 11, P.1-14.

14.  Perina EA, Ivanov VV, Pershina AG, Perekucha NA, Dzyuman AN, Kaminskii IP, Saltykova IV, Sazonov AE, Ogorodova LM. Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis. Acta Trop. 2019;192:41-48. doi: 10.1016/j.actatropica.2019.01.017.

15.  Saltykova, IV, Ittiprasert, W., Nevskaya, K. V., Dorofeeva, Y. B., Kirillova, N. A., Kulikov, E. S., ... & Brindley, P. J. 2019. Hemozoin From the Liver Fluke, Opisthorchis felineus, Modulates Dendritic Cell Responses in Bronchial Asthma Patients. Frontiers in veterinary science, 6, 332.