Will Bauer, M.S.

I research the developmental pathophysiology associated with inborn errors of cobalamin (vitamin B12) metabolism, using in vivo genetically engineered mice and in vitro patient-derived fibroblast cultures. Inborn errors of cobalamin metabolism are extensively described clinically, but there is a poor understanding of the cellular origins of associated phenotypes such as retinal degeneration, heart defects, neural tube defects, ataxia, and dementia. By using a developmental biology approach along with advanced techniques in genetics and genomics, we can begin to fill these gaps in knowledge, thereby improving our understanding of cobalamin metabolism and developing more effective therapies.

Publications

  1. Chern T, Tong X, Bauer WG, Quispe-Parra DJ, Gao X, Gerner-Mauro KN, Poché RA. “New genetic tools to define the pathophysiology of inborn errors of cobalamin metabolism impacting mammalian development.” Differentiation. 2025 May 19;143:100868. doi: 10.1016/j.diff.2025.100868. PMID: 40411980.

  2. Freeman, EJG, Bauer, WG, Easy, RH, Céspedes, RQ,Valverde, SA, Stewart, DT “Phylogenetic Analysis of the Freshwater Mussel Nephronaias tempisquensis (Bivalvia: Unionidae: Popenaiadini) from Costa Rica. Malacologia. 2025 67 (1-2).

  3. Bauer WG, Watkins D, Zacharias C, Gilfix BM, Rosenblatt DS. “Growth requirement for methionine in human melanoma-derived cell lines with different levels of MMACHC expression and methylation.” Mol Genet Metab. 2024 Jan;141(1):108111. doi: 10.1016/j.ymgme.2023.108111. Epub 2023 Dec 12.PMID: 38103461.

  4. Bauer WG, Stewart DT, Céspedes RQ, Arias S, Easy RH "DNA barcoding evidence of the tropical invasive lineage of Sinanodonta woodiana in Costa Rica." Neotrop. Nat. 2021 Jan;5:1-8.

  5. Cormier M, Ghouili F, Roumand P, Bauer WG, Touabia J, Martin LJ. “Influences of flavones on cell viability and cAMP-dependent steroidogenic gene regulation in MA-10 Leydig cells.” Cell Biol Toxi. 2018; 34(1):23-38.